Byolete

Does Dietary Cholesterol Increase Cardiovascular Risk?

Welcome back to our podcast and to a question which many want a clear answer to, does dietary cholesterol increase cardio vascular risk? Honestly, the evidence is a hard read and we invite you to listen to our opinions and more importantly, how are we going to implement the studies. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading.
If you would like to go to a particular section, please click on the time stamp below:
00:03 - Introduction
01:30 - Did you think dietary cholesterol increases serum levels?
02:43 - Why are eggs used in cholesterol studies?
03:55 - What are the current guidelines for cholesterol consumption?
05:00 - Does dietary cholesterol increase serum cholesterol?
09:16- How much dietary cholesterol do we absorb?
10:50 - Why do we have LDL cholesterol, an evolutionary trait?
13:24 - What foods are high in dietary cholesterol?
13:52 - Does saturated fat have a role to play in serum cholesterol?
17:50 - How do genetics play a part in serum cholesterol levels?
18:23 - Are we treating serum cholesterol appropriately?
19:09 - Does the gut microbiome play a role in serum cholesterol?
22:56 - What are we going to do with our diet?
27:32 - What to expect in upcoming podcasts
Sign up to our newsletter:
https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast
You can also watch this podcast episode on YouTube: https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q 
As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening!
Here is a list of the sources that we used to make this podcast:
https://www.jacc.org/doi/10.1016/j.jacc.2020.05.077
https://pmc.ncbi.nlm.nih.gov/articles/PMC9143438/#sec2-nutrients-14-02168
https://www.jlr.org/article/S0022-2275(20)33370-8/fulltext
https://www.ahajournals.org/doi/10.1161/CIR.0000000000000743
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0715-8#Sec25
https://pmc.ncbi.nlm.nih.gov/articles/PMC6024687/#notes2
https://www.cambridge.org/core/journals/nutrition-research-reviews/article/nutritional-management-of-hyperapob/FF922E54AB1189F1AF2194888D99DA0F
https://www.jlr.org/article/S0022-2275(20)33152-7/fulltext
Guyton & Hall Medical Physiology 14th edition- general physiology overview
Rang & Dale’s Pharmacology 10th edition - general pharmacological overview
Randox link:
https://www.timcogleyfoundation.com/cardiac-screening/

Why Cholesterol Matters

Welcome back to our podcast and the beginning of a mini series on cholesterol, arguably the most understood aspect of physical health. We touch upon the importance of cholesterol, the discrepancies in nomenclature surrounding cholesterol, why we should be aware of our cholesterol physiology and what we are doing from a personal point of view. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading.
If you would like to go to a particular section, please click on the time stamp below:
00:07 - Why should we be measuring cholesterol?
03:19 - Why is cholesterol important?
04:08 - Why we can’t say cholesterol is good or bad?
07:04 - Do we take our cholesterol results seriously?
09:57 - What is apoB?
11:14 - What is coming up in this lipid mini series?
Sign up to our newsletter:
https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast
You can also watch this podcast episode on YouTube: https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q 
As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening!
Here is a list of the sources that we used to make this podcast:
Guyton & Hall Medical Physiology 14th edition- general physiology overview
Rang & Dale’s Pharmacology 10th edition - general pharmacological overview
Randox link:
https://www.timcogleyfoundation.com/cardiac-screening/

GLP-1 Medications Explained by a Pharmacist | Ozempic, Wegovy, Mounjaro (Watch Before Starting)

Welcome to our discussion on GLP-1 medication in the context of their weight loss licensing. All medication comes with risk, but as this class of medication has many benefits, including aesthetics, we believe many people have lost touch with the fact that these are regulated medication. We have became aware of online communities providing medical advice for GLP-1 medication, this is highly dangerous and this should not be a primary source of information and should be discussed with your healthcare team. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading.
If you would like to go to a particular section, please click on the time stamp below (please note this podcast was extremely hard to time stamp, so we did our best):
00:08 - Why are we discussing GLP-1 medications again?
01:54 - Online weight-loss communities are more detrimental than good
09:58 - How is medication regulated in the UK?
16:32 - Are online pharmacies helping the situation?
20:34 - GLP-1 medication does require you to adopt a healthy lifestyle
21:58 - The controversial aspects of health?
28:52 - Social media versus health care professionals
29:58 - Let’s discuss ‘Big Pharma’
33:08 - Our final thoughts and key points
Here is our podcast link:
https://open.spotify.com/show/5kJoyk0uY8u1H8CmgNDWzo?si=JF4_mY8oSES520KcOaHwhA
Sign up to our newsletter:
https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast
You can also watch this podcast episode on YouTube: https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q 
As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening!
Here is a list of the sources that we used to make this podcast:
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
https://www.nejm.org/doi/full/10.1056/NEJMoa1411892
https://www.nejm.org/doi/10.1056/NEJMoa2032183?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Rang & Dale’s Pharmacology 10th edition - general pharmacological overview

Is it Dangerous to Drink Alcohol on Medication?

Welcome to the final episode of this alcohol series, this week we discuss the interactions of alcohol with common medication that you may encounter. As always, our aim is to provide the evidence for you to decide whether alcohol should be apart of your lifestyle and we do so in an unbiased fashion. Within this episode we assess the evidence relating to the proposed mechanism of interactions, proposed outcome and what this means in a practical sense. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading.
If you would like to go to a particular section, please click on the time stamp below:
00:07 - Welcome back
00:54 - What did we think of alcohol with medication?
02:12 - How can drugs interact with each other?
02:58 - How can alcohol interact with commonly bought medication?
09:27 - How does alcohol interact with drugs that act on the CNS?
12:37 - What should I be cautious of when taking alcohol with anti-microbial medication?
16:39 - How does alcohol interfere with drugs that work on the cardiovascular system?
18:58 - Alcohol and diabetic medication interaction?
20:07 - Key points to note about alcohol with medication
20:51 - Final thoughts
Sign up to our newsletter:
https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast
You can also watch this podcast episode on YouTube: https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q 
As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening!
Here is a list of the sources that we used to make this podcast:
https://pmc.ncbi.nlm.nih.gov/articles/PMC4498995/#:~:text=Glucuronidation%20is%20the%20main%20pathway,detoxified%20by%20the%20glutathione%20pathway
https://pmc.ncbi.nlm.nih.gov/articles/PMC7038249/#:~:text=Available%20data%20support%20that%20oral,are%20equivocal%20for%20trimethoprim%2Dsulfamethoxazole
Rang & Dale’s Pharmacology 10th edition - general pharmacological overview
https://www.alcoholics-anonymous.org.uk/ - Alcoholic anonymous

The Benefits of Alcohol

Welcome to the 3rd episode of our alcohol series, this week we discuss the perceived benefits of alcohol for our health. As always, our aim is to provide the evidence for you to decide whether alcohol should be apart of your lifestyle and we do so in an unbiased fashion. Within this episode we assess the evidence relating to cardiovascular health, social implications and current uses in therapeutic medicine. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading.
If you would like to go to a particular section, please click on the time stamp below:
00:07 - What were our initial instincts surrounding alcohol benefits?
04:15 - What are the uses of alcohol?
05:36 - Social benefits of alcohol, what is the evidence?
11:44 - Is alcohol beneficial for your cardiovascular health?
19:30 - Do we agree to alcohol having any benefit?
23:25 - Alcohol use in medicinal formulations
26:25 - Our final opinion and thoughts on alcohol
Sign up to our newsletter:
https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast
You can also watch this podcast episode on YouTube: https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q 
As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening!
Here is a list of the sources that we used to make this podcast:
https://link.springer.com/article/10.1007/s40750-016-0058-4
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02911 w#:~:text=The%20“J%2Dshaped”%20relationship,it%20greatly%20increases%20health%20risks.
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02907-6
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802963
https://www.ncbi.nlm.nih.gov/books/NBK556147/
https://www.ema.europa.eu/en/documents/scientific-guideline/information-package-leaflet-regarding-ethanol-used-excipient-medicinal-products-human-use_en.pdf
https://www.bmj.com/content/363/bmj.k4370/rr-2
https://www.sciencedirect.com/science/article/abs/pii/S0378517324001273
https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1360-0443.1996.911255.x#:~:text=The%20British%20Medical%20Association%20recently,sensible%20drinking%2C%20obtainable%20from%20British
Rang & Dale’s Pharmacology 10th edition - general pharmacological overview
https://www.alcoholics-anonymous.org.uk/ - Alcoholic anonymous

Complications of Alcohol Use

Welcome to the 2nd episode of our alcohol series, this week we discuss both the acute and chronic complications cited with regular consumption. As always, our aim is to provide the evidence for you to decide whether alcohol should be apart of your lifestyle and we do so in an unbiased fashion. Within this episode we assess the evidence relating to cognitive impairment, alcohol-associated liver disease, use of alcohol in pregnancy, the effect on the microbiome and whether there is still a stigma surrounding alcohol? There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading.
If you would like to go to a particular section, please click on the time stamp below:
00:07 - Introduction & alcohol statistics
03:10 - Acute complications of alcohol
09:12 - Where did the ‘hangover’ originate?
11:30 - Does alcohol increase cognitive impairment?
15:26 - What is Wernicke’s encephalopathy?
17:24 - How is the liver affected by the alcoholic onslaught?
20:41 - Does alcohol impact the microbiome?
22:04 - What are the complications of cirrhosis?
25:25 - Is there still a stigma around alcohol?
28:37 - Our survey says we want to socially drink!
30:46 - Fetal alcoholic syndrome, the risks around pregnancy
32:46 - Alcoholic complications key points
36:16 - Respect people’s choice not to drink
37:46 - Final thoughts
Here is a list of the sources that we used to make this podcast:
https://www.bmj.com/content/357/bmj.j2353?ijkey=78857d459765a35099284fe4b337607a4a8981f2&keytype2=tf_ipsecsha- cognitive impairment
https://www.bmj.com/content/383/bmj-2023-077090 - Alcohol associated liver disease; microbiome dysfunction and general overview
https://www.gov.uk/government/statistics/reported-road-casualties-in-great-britain-involving-illegal-alcohol-levels-2021/reported-road-casualties-in-great-britain-involving-illegal-alcohol-levels-2021 - drink driving statistics
https://alcoholchange.org.uk/alcohol-facts/fact-sheets/alcohol-statistics?gad_source=1&gclid=CjwKCAjwjsi4BhB5EiwAFAL0YDoiCx0W2Nj8pRbtf-mhAt4awwbUTtlq1DhmDeacEfzrB5oeH3LWExoCo7IQAvD_BwE- general alcohol statistics
https://jech.bmj.com/content/68/6/542 - pregnancy study
Rang & Dale’s Pharmacology 10th edition - general pharmacological overview
https://www.alcoholics-anonymous.org.uk/ - Alcoholic anonymous
Sign up to our newsletter:
https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast
You can also watch this podcast episode on YouTube: https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q 
As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening!

Alcohol- Know The Basics

This episode is the start of a 4 part series, researching the origins of alcohol, the physiology, complications, benefits and interference with other medication. Our aim is to provide the evidence, for you to decide whether alcohol should be apart of your lifestyle and we do so in an unbiased fashion. Within this episode we venture into when alcohol was first referenced, what is the current recommended guidelines, how alcohol exerts its effects, what processes does the body possess to cope with alcohol consumption, are there any social implications with alcohol and our personal experiences.
If you would like to go to a particular section, please click on the time stamp below:
00:00 - Introduction & Why did we pick alcohol as a topic?
02:16 - What is the history of alcohol?
11:11 - What is a unit of alcohol? What are the current alcohol guidelines?
14:46 - How does our body deal with alcohol and how does alcohol exert its effects?
24:36 - What is our experience of alcohol? What are the social pressures?
30:36 - Final thoughts
Here is a list of the sources that we used to make this podcast:
https://assets.publishing.service.gov.uk/media/5a80b7ed40f0b623026951db/UK_CMOs__report.pdf - low risk drinking guidelines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671803/ - molecular action of alcohol
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527027/ - metabolism of alcohol
Rang & Dale’s Pharmacology 10th edition - general pharmacological overview
Sign up to our newsletter:
https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast
You can also watch this podcast episode on YouTube: 
https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q 
As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening!

How to Manage Type 2 Diabetes: Essential Diet, Lifestyle Tips & Medication Strategies

Type 2 diabetes was once believed to be a lifelong condition, however, evidence now suggests that we can put this into remission. In this episode, we focus on how diet and exercise can have the biggest impact, an area of management that was quickly glazed over in the past. Also, we explain the current pharmacological guidelines, advise on circumstances to monitor whilst taking the medication and offer some personal insight.
As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and please subscribe for future episodes, thanks for listening!
You can skip to the relevant sections if needed:
(00:00-01:15) - Introduction
(01:16-27:57) - Diet & lifestyle
(27:57-47:26) - Medication
(47:27-48:48) - Final Thoughts
For this episode we reviewed NICE guidelines, the manufacturer's summary of product characteristics (for each medication) and Rang & Dale's pharmacology. We also discussed the findings of the DiRECT:
https://www.thelancet.com/action/showPdf?pii=S2213-8587%2823%2900385-6
You can also watch this podcast episode on YouTube: 
https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q