How to Lower Your ApoB | Is the Gut Microbiome Involved in Cholesterol Metabolism?

Welcome back to our podcast, in this episode we discuss how we are going to act upon our ApoB results that we shared previously. We aim to apply the current studies to our lifestyle and measure how effective our interventions have been in 3-4 months. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading. If you would like to go to a particular section, please click on the time stamp below: 00:03 - Introduction 02:35 - How is the microbiome involved in cholesterol metabolism? 03:23- Coprostanol and its role in cholesterol homeostasis 04:27 - Cholesterol entrapment via gut bacteria 05:43 - Secondary bile acids produced by the gut microbiome 08:08 - The importance of a diverse gut microbiome 12:56 - How to increase your plant intake 14:14 - importance of probiotic for gut microbiome diversity 14:40 - prebiotics and the microbiome 15:09 - Can alcohol theoretically decrease the diversity of the gut microbiome? 16:14 - Is it easy for people with IBS to improve their gut microbiome? 18:18 - Fasting window and gut health 19:14 - antibiotic use and the impact on the gut microbiome 21:25 - does decreasing saturated fats in your diet have a direct effect on cholesterol/ APOB levels 24:18 - Impact of exercise on CVD risk, APOB and LDL-C 25:05 - how energy is used during different intensities of exercise - VO2max 31:03 - dietary carbohydrate consumption and its role in CVD risk 36:28 - Summary - what are we going to be doing going forward to improve our biomarkers? 41:05 - outro Here are our podcast links: https://open.spotify.com/show/5kJoyk0uY8u1H8CmgNDWzo?si=JF4_mY8oSES520KcOaHwhA https://podcasts.apple.com/us/podcast/the-chemist-couple-podcast/id1773332678 Sign up to our newsletter and stay up to date with how we personally apply the science to enhance our lifestyle: https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast You can also watch this podcast episode on YouTube: https://www.youtube.com/channel/UCAf1zFQF4_dyVG4z8DD0_3Q  As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening! Here is a list of the sources that we used to make this podcast: https://pmc.ncbi.nlm.nih.gov/articles/PMC4242964/#:~:text=Recently%2C%20regular%20exercise%20has%20been,apoA1%20ratio%20demonstrated%20significant%20interactions - exercise in overweight women on ApoB https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1365-2796.2007.01806.x - exercise on ApoB- predominantly males https://pmc.ncbi.nlm.nih.gov/articles/PMC5972657/#sec4 - saturated fats on ApoB https://pmc.ncbi.nlm.nih.gov/articles/PMC7468809/#sec1-nutrients-12-02204 - Glycaemic index & load on lipid kinetics https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.315766#graphical-abstract - Saturated fats increasing atherogenicity of LDL-c https://pmc.ncbi.nlm.nih.gov/articles/PMC7416843/ - gut microbiome & CVD https://pmc.ncbi.nlm.nih.gov/articles/PMC7049528/ - high fibre diets on short chain fatty acids https://pmc.ncbi.nlm.nih.gov/articles/PMC7230435/ - Gut microbiome & intestinal permeability Guyton & Hall Medical Physiology 14th edition- general physiology overview Rang & Dale’s Pharmacology 10th edition - general pharmacological overview Links to cardiac screening - North West, UK https://www.timcogleyfoundation.com https://healthchecks.randoxhealth.com/tim-cogley-foundation